RAB6B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_1903292Biological processprotein localization to Golgi membrane
GO_0007030Biological processGolgi organization
GO_0006886Biological processintracellular protein transport
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0006891Biological processintra-Golgi vesicle-mediated transport
GO_0031175Biological processneuron projection development
GO_0000139Cellular componentGolgi membrane
GO_0098793Cellular componentpresynapse
GO_0005829Cellular componentcytosol
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005794Cellular componentGolgi apparatus
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012505Cellular componentendomembrane system
GO_0031489Molecular functionmyosin V binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB6B
Protein nameGTP-binding protein RAB6B
Ras-related protein Rab-6B (EC 3.6.5.2)
RAB6B, member RAS oncogene family
RAB6B protein
Synonyms
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Recruits VPS13B to the Golgi membrane . Regulates the compacted morphology of the Golgi . Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells . Plays a role in neuron projection development . .

AccessionsENST00000486858.5 [Q9NRW1-2]
J3KR73
C9J0I2
Q9UL29
ENST00000543906.5 [Q9NRW1-1]
ENST00000285208.9 [Q9NRW1-1]
ENST00000477759.5
C9JB90
Q9NRW1
C9JU14
ENST00000460865.3
Q6AZ91
ENST00000469959.1
ENST00000488969.1