RAB39B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RAB39B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAB39B at tissue level.

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0016192Biological processvesicle-mediated transport
GO_0032482Biological processRab protein signal transduction
GO_0010506Biological processregulation of autophagy
GO_0050808Biological processsynapse organization
GO_0031982Cellular componentvesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0043005Cellular componentneuron projection
GO_0031489Molecular functionmyosin V binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB39B
Protein nameRas-related protein Rab-39B
Synonyms
DescriptionFUNCTION: Small GTPases Rab involved in autophagy . The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity). .

AccessionsQ96DA2
ENST00000369454.4