I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 4 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| microglial cell | 4 studies | 23% ± 5% |
Insufficient scRNA-seq data for expression of RAB39A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 94% | 50.22 | 2494 / 2642 | 96% | 5.74 | 674 / 705 |
| lung | 94% | 35.37 | 541 / 578 | 48% | 1.34 | 553 / 1155 |
| adrenal gland | 87% | 21.44 | 224 / 258 | 51% | 2.50 | 117 / 230 |
| breast | 77% | 14.31 | 353 / 459 | 37% | 1.13 | 418 / 1118 |
| kidney | 69% | 12.87 | 61 / 89 | 44% | 1.27 | 395 / 901 |
| intestine | 86% | 18.63 | 832 / 966 | 24% | 0.62 | 124 / 527 |
| spleen | 99% | 77.34 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 92% | 31.29 | 1110 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 52% | 6.89 | 186 / 359 | 39% | 1.31 | 111 / 286 |
| bladder | 67% | 13.19 | 14 / 21 | 20% | 0.53 | 99 / 504 |
| esophagus | 54% | 7.93 | 775 / 1445 | 27% | 1.10 | 50 / 183 |
| peripheral blood | 81% | 39.40 | 748 / 929 | 0% | 0 | 0 / 0 |
| prostate | 61% | 8.22 | 149 / 245 | 18% | 0.39 | 88 / 502 |
| skin | 27% | 3.15 | 494 / 1809 | 46% | 1.19 | 216 / 472 |
| pancreas | 45% | 5.94 | 148 / 328 | 21% | 0.50 | 38 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 62% | 3.39 | 18 / 29 |
| blood vessel | 61% | 12.79 | 817 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 47% | 5.21 | 80 / 170 | 14% | 0.35 | 62 / 459 |
| thymus | 52% | 7.68 | 338 / 653 | 9% | 0.24 | 53 / 605 |
| ovary | 27% | 3.11 | 49 / 180 | 24% | 0.44 | 104 / 430 |
| heart | 43% | 5.95 | 370 / 861 | 0% | 0 | 0 / 0 |
| liver | 33% | 5.23 | 75 / 226 | 6% | 0.14 | 24 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.65 | 13 / 45 |
| muscle | 16% | 1.53 | 125 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 10% | 0.16 | 8 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015031 | Biological process | protein transport |
| GO_0006914 | Biological process | autophagy |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0032482 | Biological process | Rab protein signal transduction |
| GO_0090385 | Biological process | phagosome-lysosome fusion |
| GO_0090383 | Biological process | phagosome acidification |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0045335 | Cellular component | phagocytic vesicle |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0005525 | Molecular function | GTP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | RAB39A |
| Protein name | Ras-related protein Rab-39A (Rab-39) |
| Synonyms | RAB39 |
| Description | FUNCTION: Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K . May be involved in multiple neurite formation (By similarity). . |
| Accessions | Q14964 ENST00000320578.3 |
