RAB35 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAB35 at tissue level.

III. Associated gene sets

GO_0031175Biological processneuron projection development
GO_0032482Biological processRab protein signal transduction
GO_0000281Biological processmitotic cytokinesis
GO_0032456Biological processendocytic recycling
GO_0016197Biological processendosomal transport
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0048227Biological processplasma membrane to endosome transport
GO_0019882Biological processantigen processing and presentation
GO_0015031Biological processprotein transport
GO_0008104Biological processprotein localization
GO_0036010Biological processprotein localization to endosome
GO_0005886Cellular componentplasma membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0045171Cellular componentintercellular bridge
GO_0005829Cellular componentcytosol
GO_0031253Cellular componentcell projection membrane
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0010008Cellular componentendosome membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0042470Cellular componentmelanosome
GO_0019003Molecular functionGDP binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB35
Protein nameRAB35, member RAS oncogene family
Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C)
SynonymsRAY
RAB1C
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. .

AccessionsENST00000229340.10 [Q15286-1]
F5H7F8
F5H157
ENST00000544304.5
Q15286
ENST00000538903.1
ENST00000534951.5 [Q15286-2]