RAB23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0000045Biological processautophagosome assembly
GO_0046039Biological processGTP metabolic process
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0006886Biological processintracellular protein transport
GO_0006968Biological processcellular defense response
GO_0097094Biological processcraniofacial suture morphogenesis
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0030054Cellular componentcell junction
GO_0010008Cellular componentendosome membrane
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB23
Protein nameRas-related protein Rab-23
SynonymsHSPC137
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. .

AccessionsQ9ULC3
ENST00000468148.6
ENST00000317483.4