QPCT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0017186Biological processpeptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
GO_0036211Biological processprotein modification process
GO_1904724Cellular componenttertiary granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0035580Cellular componentspecific granule lumen
GO_0005576Cellular componentextracellular region
GO_0016603Molecular functionglutaminyl-peptide cyclotransferase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameQPCT
Protein nameGlutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)
Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase)
Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (Glutaminyl-tRNA cyclotransferase)
Synonyms
DescriptionFUNCTION: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. .

AccessionsENST00000404976.5
C9JS14
ENST00000650442.1
B5MCZ9
Q16769
A0A3B3IUD5
ENST00000444022.1
ENST00000338415.8 [Q16769-1]