QNG1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of QNG1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of QNG1 at tissue level.

III. Associated gene sets

GO_0101030Biological processtRNA-guanine transglycosylation
GO_0043174Biological processnucleoside salvage
GO_0008150Biological processbiological_process
GO_0005575Cellular componentcellular_component
GO_0016787Molecular functionhydrolase activity
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameQNG1
Protein nameQueuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Queuosine-nucleotide N-glycosylase/hydrolase)
Queuosine 5'-phosphate N-glycosylase/hydrolase (EC 3.2.2.-) (Q-nucleotide N-glycosylase 1) (Queuine salvage protein QNG1) (Queuosine-nucleotide N-glycosylase/hydrolase)
SynonymshCG_2042994
C9orf64
DescriptionFUNCTION: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. In vitro, can also catalyze the release of the q base directly from Q as substrate; however, it was shown that Q is not the biologically relevant substrate. Shows a very low activity on queuosine 3',5'-diphosphate, and cannot release q from queuosine 3'-phosphate and from the 5'-nucleotides AMP, UMP, CMP or GMP, indicating specificity for the queuine base . Can complement the yeast mutant SPAC589.05c, restoring Q incorporation into tRNA . .

FUNCTION: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. .

FUNCTION: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. .

AccessionsQ5T6V6
Q5T6V7
ENST00000376340.2
ENST00000376344.8
Q5T6V5
ENST00000314700.5