PYGB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005980Biological processglycogen catabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0102499Molecular functionSHG alpha-glucan phosphorylase activity
GO_0008184Molecular functionglycogen phosphorylase activity
GO_0005515Molecular functionprotein binding
GO_0102250Molecular functionlinear malto-oligosaccharide phosphorylase activity
GO_0030170Molecular functionpyridoxal phosphate binding

IV. Literature review

[source]
Gene namePYGB
Protein nameGlycogen phosphorylase, brain form (EC 2.4.1.1)
Alpha-1,4 glucan phosphorylase (EC 2.4.1.1)
Synonyms
DescriptionFUNCTION: Glycogen phosphorylase that regulates glycogen mobilization . Phosphorylase is an important allosteric enzyme in carbohydrate metabolism . Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates . However, all known phosphorylases share catalytic and structural properties . .

FUNCTION: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. .

AccessionsENST00000216962.9
ENST00000428458.1
H0Y4Z6
P11216