I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 26% ± 9% | |
| connective tissue cell | 3 studies | 44% ± 19% | |
| epithelial cell | 3 studies | 35% ± 13% | |
| goblet cell | 3 studies | 29% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 6 studies | 26% ± 9% | |
| connective tissue cell | 3 studies | 44% ± 19% | |
| epithelial cell | 3 studies | 35% ± 13% | |
| goblet cell | 3 studies | 29% ± 7% |
Insufficient scRNA-seq data for expression of PYCR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 99% | 1382.42 | 243 / 245 | 99% | 162.16 | 497 / 502 |
| pancreas | 100% | 3007.71 | 328 / 328 | 92% | 37.43 | 164 / 178 |
| lung | 92% | 760.90 | 532 / 578 | 95% | 82.33 | 1102 / 1155 |
| stomach | 90% | 1525.04 | 322 / 359 | 98% | 94.68 | 279 / 286 |
| brain | 96% | 411.21 | 2524 / 2642 | 90% | 36.75 | 638 / 705 |
| skin | 80% | 1304.31 | 1443 / 1809 | 96% | 68.78 | 451 / 472 |
| breast | 75% | 467.72 | 345 / 459 | 98% | 90.14 | 1097 / 1118 |
| intestine | 72% | 577.14 | 697 / 966 | 97% | 105.04 | 512 / 527 |
| ovary | 71% | 359.43 | 127 / 180 | 94% | 50.96 | 406 / 430 |
| esophagus | 62% | 405.38 | 890 / 1445 | 92% | 55.30 | 168 / 183 |
| uterus | 70% | 420.97 | 119 / 170 | 80% | 49.99 | 365 / 459 |
| bladder | 57% | 578.90 | 12 / 21 | 82% | 66.07 | 412 / 504 |
| liver | 53% | 211.85 | 119 / 226 | 34% | 14.55 | 139 / 406 |
| eye | 0% | 0 | 0 / 0 | 86% | 27.71 | 69 / 80 |
| spleen | 84% | 383.95 | 203 / 241 | 0% | 0 | 0 / 0 |
| muscle | 83% | 365.97 | 669 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 31.24 | 36 / 45 |
| thymus | 66% | 268.69 | 430 / 653 | 14% | 4.42 | 85 / 605 |
| adrenal gland | 47% | 155.67 | 120 / 258 | 29% | 8.62 | 66 / 230 |
| heart | 67% | 292.12 | 574 / 861 | 0% | 0 | 0 / 0 |
| kidney | 49% | 146.19 | 44 / 89 | 15% | 5.51 | 131 / 901 |
| blood vessel | 57% | 259.53 | 765 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 51% | 235.29 | 617 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 31% | 7.55 | 9 / 29 |
| peripheral blood | 24% | 775.68 | 223 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051881 | Biological process | regulation of mitochondrial membrane potential |
| GO_0006561 | Biological process | proline biosynthetic process |
| GO_0034599 | Biological process | cellular response to oxidative stress |
| GO_0055129 | Biological process | L-proline biosynthetic process |
| GO_1903377 | Biological process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004735 | Molecular function | pyrroline-5-carboxylate reductase activity |
| Gene name | PYCR1 |
| Protein name | Pyrroline-5-carboxylate reductase (EC 1.5.1.2) Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) Pyrroline-5-carboxylate reductase 1 Truncated pyrroline-5-carboxylate reductase 1 pyrroline-5-carboxylate reductase (EC 1.5.1.2) |
| Synonyms | hCG_38803 |
| Description | FUNCTION: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. . |
| Accessions | ENST00000619204.4 [P32322-1] ENST00000577624.5 J3KSA9 J3KQ22 ENST00000581271.5 J3QKT4 E2QRB3 ENST00000582198.5 J3QRZ0 ENST00000585244.1 ENST00000629768.2 J3QLK9 ENST00000337943.9 [P32322-2] ENST00000579366.5 J3QL24 J3QL23 ENST00000577756.5 J3KTA8 J3QKT3 ENST00000329875.13 [P32322-1] ENST00000584848.5 ENST00000402252.6 [P32322-3] J3QL32 D6QXZ5 J3QR88 ENST00000579698.5 A0A1B2JLU7 ENST00000585215.5 ENST00000405481.8 ENST00000403172.8 P32322 ENST00000583564.5 |
