PXYLP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010909Biological processpositive regulation of heparan sulfate proteoglycan biosynthetic process
GO_0050650Biological processchondroitin sulfate proteoglycan biosynthetic process
GO_0016311Biological processdephosphorylation
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePXYLP1
Protein name2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)
2-phosphoxylose phosphatase 1 (Acid phosphatase-like protein 2)
2-phosphoxylose phosphatase 1
SynonymsACPL2
HEL124
UNQ370/PRO706
XYLP
DescriptionFUNCTION: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. .

AccessionsENST00000637579.1
D6RDP0
ENST00000513528.5
ENST00000508812.1
D6R928
A0A1B0GUH7
ENST00000636601.1
D6RGE3
D6RE60
Q8TE99
ENST00000393010.6 [Q8TE99-1]
B7Z3R9
ENST00000514680.5
ENST00000514880.5
ENST00000512457.5
E9PDB7
ENST00000286353.9 [Q8TE99-1]
ENST00000505013.5
ENST00000504264.5
ENST00000502783.5
A0A1B0GWB5
ENST00000637751.1
B7Z4T2