PWWP2B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PWWP2B at tissue level.

III. Associated gene sets

GO_0120161Biological processregulation of cold-induced thermogenesis
GO_0006338Biological processchromatin remodeling
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0120325Molecular functionNuRD complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePWWP2B
Protein namePWWP domain-containing protein 2B
SynonymsPWWP2
DescriptionFUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes . Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z . Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). .

AccessionsENST00000305233.6 [Q6NUJ5-1]
Q6NUJ5
ENST00000631148.2 [Q6NUJ5-2]