PWP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PWP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PWP2 at tissue level.

III. Associated gene sets

GO_0000028Biological processribosomal small subunit assembly
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042274Biological processribosomal small subunit biogenesis
GO_0034388Cellular componentPwp2p-containing subcomplex of 90S preribosome
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePWP2
Protein namePWP2 small subunit processome component
Periodic tryptophan protein 2 homolog
SynonymsPWP2H
DescriptionFUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. .

AccessionsC9J544
ENST00000456705.1
Q15269
ENST00000291576.12