PVRIG report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PVRIG at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PVRIG at tissue level.

III. Associated gene sets

GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0019902Molecular functionphosphatase binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePVRIG
Protein namePVR related immunoglobulin domain containing
Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein)
SynonymsC7orf15
DescriptionFUNCTION: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. .

AccessionsQ6DKI7
ENST00000317271.3
A0A8V8TN58
ENST00000699088.1