PUS10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031119Biological processtRNA pseudouridine synthesis
GO_0031053Biological processprimary miRNA processing
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0009982Molecular functionpseudouridine synthase activity
GO_0070878Molecular functionprimary miRNA binding
GO_0106029Molecular functiontRNA pseudouridine synthase activity
GO_0005515Molecular functionprotein binding
GO_0160148Molecular functiontRNA pseudouridine(55) synthase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePUS10
Protein nametRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase)
Pseudouridine synthase 10
SynonymsDOBI
CCDC139
DescriptionFUNCTION: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm . In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs . tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs . Does not show tRNA pseudouridylate synthase activity in the nucleus . In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity . Binds pri-miRNAs . Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage . Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death . .

AccessionsENST00000430495.5
C9JNL8
Q3MIT2
ENST00000407787.5
ENST00000421319.5
A8MUL8
ENST00000398658.2
ENST00000316752.11