PUS1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	21% ± 3%	Explore

Name	Number of supported studies	Average coverage
liver	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1284.30	1445 / 1445	100%	14.04	183 / 183
liver	100%	1277.88	226 / 226	100%	13.27	406 / 406
ovary	100%	871.58	180 / 180	100%	12.54	430 / 430
uterus	100%	1067.63	170 / 170	100%	19.34	459 / 459
bladder	100%	1353.76	21 / 21	100%	22.28	503 / 504
thymus	100%	1077.46	653 / 653	100%	11.03	603 / 605
stomach	100%	999.70	359 / 359	100%	19.33	285 / 286
intestine	100%	1171.34	966 / 966	100%	24.70	525 / 527
pancreas	100%	851.82	328 / 328	99%	13.50	177 / 178
prostate	100%	1294.40	245 / 245	99%	11.34	499 / 502
skin	100%	1480.56	1809 / 1809	99%	14.86	469 / 472
lung	100%	953.22	576 / 578	99%	15.41	1147 / 1155
adrenal gland	100%	1390.71	258 / 258	99%	10.56	227 / 230
brain	99%	886.89	2622 / 2642	99%	8.44	701 / 705
breast	100%	1046.78	459 / 459	99%	12.47	1103 / 1118
kidney	100%	1036.83	89 / 89	98%	9.62	887 / 901
adipose	100%	1061.33	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	12.93	80 / 80
lymph node	0%	0	0 / 0	100%	29.55	29 / 29
spleen	100%	1811.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	15.51	45 / 45
ureter	0%	0	0 / 0	100%	20.81	1 / 1
blood vessel	100%	676.65	1331 / 1335	0%	0	0 / 0
muscle	99%	679.38	791 / 803	0%	0	0 / 0
heart	97%	532.28	835 / 861	0%	0	0 / 0
peripheral blood	91%	887.88	848 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1990481	Biological process	mRNA pseudouridine synthesis
GO_0031119	Biological process	tRNA pseudouridine synthesis
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0070902	Biological process	mitochondrial tRNA pseudouridine synthesis
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0009982	Molecular function	pseudouridine synthase activity
GO_0000049	Molecular function	tRNA binding
GO_0002153	Molecular function	steroid receptor RNA activator RNA binding
GO_0160147	Molecular function	tRNA pseudouridine(38-40) synthase activity
GO_0003723	Molecular function	RNA binding

Gene name	PUS1
Protein name	Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) Pseudouridine synthase 1
Synonyms	PP8985
Description	FUNCTION: Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs . Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA . Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' . Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing . Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA . .
Accessions	F5GY32 F5H1B2 ENST00000456665.6 ENST00000537484.1 ENST00000443358.6 [Q9Y606-2] F5H1S9 ENST00000544213.5 ENST00000322060.9 ENST00000542167.2 Q9Y606 ENST00000538037.5 ENST00000535067.5 F5H168 F8W9U5 F5GXL3 G8JLB3 ENST00000376649.8 [Q9Y606-1]

PUS1 report