PTPMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032049Biological processcardiolipin biosynthetic process
GO_2001242Biological processregulation of intrinsic apoptotic signaling pathway
GO_0005634Cellular componentnucleus
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0017018Molecular functionmyosin phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0008962Molecular functionphosphatidylglycerophosphatase activity
GO_0004439Molecular functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPMT1
Protein namePhosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16, EC 3.1.3.48)
Protein tyrosine phosphatase mitochondrial 1
SynonymsMOSP
PLIP
PNAS-129
DescriptionFUNCTION: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity . .

AccessionsENST00000326656.12 [Q8WUK0-2]
E9PQM0
ENST00000534775.1
ENST00000326674.10 [Q8WUK0-1]
ENST00000426530.2 [Q8WUK0-3]
Q8WUK0