PTGDS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019371Biological processcyclooxygenase pathway
GO_2000255Biological processnegative regulation of male germ cell proliferation
GO_0043303Biological processmast cell degranulation
GO_0051384Biological processresponse to glucocorticoid
GO_0001516Biological processprostaglandin biosynthetic process
GO_0045187Biological processregulation of circadian sleep/wake cycle, sleep
GO_0010467Biological processgene expression
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0005504Molecular functionfatty acid binding
GO_0005501Molecular functionretinoid binding
GO_0004667Molecular functionprostaglandin-D synthase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTGDS
Protein nameProstaglandin-H2 D-isomerase (EC 5.3.99.2) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase)
Prostaglandin D2 synthase
Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
SynonymsPDS
DescriptionFUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation . Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system . Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). .

AccessionsP41222
ENST00000371625.8
H0Y5A1
H0Y4L4
ENST00000446677.2
ENST00000457950.5
ENST00000640716.1
A0A1W2PPU3
Q5SQ11
ENST00000444903.2