Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 35 studies | 49% ± 22% | |
astrocyte | 20 studies | 71% ± 20% | |
plasmacytoid dendritic cell | 19 studies | 38% ± 10% | |
endothelial cell | 16 studies | 39% ± 20% | |
oligodendrocyte | 15 studies | 74% ± 14% | |
natural killer cell | 12 studies | 22% ± 5% | |
connective tissue cell | 10 studies | 51% ± 20% | |
oligodendrocyte precursor cell | 10 studies | 36% ± 18% | |
CD16-positive, CD56-dim natural killer cell, human | 8 studies | 22% ± 5% | |
smooth muscle cell | 7 studies | 50% ± 22% | |
pericyte | 6 studies | 36% ± 11% | |
microglial cell | 6 studies | 50% ± 23% | |
vein endothelial cell | 5 studies | 47% ± 18% | |
retinal pigment epithelial cell | 5 studies | 75% ± 20% | |
adventitial cell | 5 studies | 31% ± 12% | |
Mueller cell | 5 studies | 83% ± 17% | |
macrophage | 4 studies | 34% ± 13% | |
podocyte | 4 studies | 62% ± 30% | |
retinal ganglion cell | 4 studies | 31% ± 7% | |
endothelial cell of artery | 4 studies | 25% ± 7% | |
GABAergic neuron | 3 studies | 28% ± 13% | |
glutamatergic neuron | 3 studies | 33% ± 16% | |
glycinergic amacrine cell | 3 studies | 31% ± 4% | |
myofibroblast cell | 3 studies | 47% ± 33% | |
amacrine cell | 3 studies | 36% ± 12% | |
cardiac muscle cell | 3 studies | 19% ± 4% | |
epithelial cell | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 55551.93 | 2626 / 2642 | 95% | 30.25 | 672 / 705 |
prostate | 83% | 24621.04 | 203 / 245 | 71% | 5.18 | 357 / 502 |
lung | 82% | 18271.45 | 474 / 578 | 31% | 1.56 | 355 / 1155 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.28 | 1 / 1 |
heart | 98% | 96459.76 | 841 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 40.08 | 27 / 29 |
ovary | 6% | 978.86 | 11 / 180 | 73% | 13.76 | 313 / 430 |
uterus | 45% | 10424.83 | 77 / 170 | 31% | 2.52 | 141 / 459 |
spleen | 74% | 9887.76 | 179 / 241 | 0% | 0 | 0 / 0 |
kidney | 65% | 11290.54 | 58 / 89 | 8% | 1.65 | 76 / 901 |
pancreas | 0% | 29.59 | 1 / 328 | 66% | 4.53 | 117 / 178 |
adrenal gland | 47% | 7983.77 | 121 / 258 | 10% | 0.89 | 22 / 230 |
skin | 14% | 1845.07 | 258 / 1809 | 35% | 3.44 | 165 / 472 |
adipose | 34% | 5517.81 | 412 / 1204 | 0% | 0 | 0 / 0 |
intestine | 11% | 1546.36 | 107 / 966 | 22% | 1.04 | 117 / 527 |
bladder | 14% | 1573.76 | 3 / 21 | 18% | 1.26 | 92 / 504 |
stomach | 6% | 602.84 | 21 / 359 | 23% | 1.48 | 66 / 286 |
tonsil | 0% | 0 | 0 / 0 | 27% | 1.48 | 12 / 45 |
breast | 15% | 1917.06 | 70 / 459 | 11% | 0.60 | 125 / 1118 |
eye | 0% | 0 | 0 / 0 | 26% | 1.65 | 21 / 80 |
esophagus | 10% | 1568.35 | 149 / 1445 | 15% | 0.57 | 27 / 183 |
liver | 1% | 163.86 | 3 / 226 | 21% | 8.48 | 84 / 406 |
thymus | 4% | 456.89 | 24 / 653 | 18% | 2.62 | 108 / 605 |
blood vessel | 18% | 3492.40 | 245 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 4% | 616.76 | 37 / 929 | 0% | 0 | 0 / 0 |
muscle | 2% | 157.21 | 13 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019371 | Biological process | cyclooxygenase pathway |
GO_2000255 | Biological process | negative regulation of male germ cell proliferation |
GO_0043303 | Biological process | mast cell degranulation |
GO_0051384 | Biological process | response to glucocorticoid |
GO_0001516 | Biological process | prostaglandin biosynthetic process |
GO_0045187 | Biological process | regulation of circadian sleep/wake cycle, sleep |
GO_0010467 | Biological process | gene expression |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005791 | Cellular component | rough endoplasmic reticulum |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005504 | Molecular function | fatty acid binding |
GO_0005501 | Molecular function | retinoid binding |
GO_0004667 | Molecular function | prostaglandin-D synthase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PTGDS |
Protein name | Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) Prostaglandin D2 synthase Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2) |
Synonyms | PDS |
Description | FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation . Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system . Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). . |
Accessions | P41222 ENST00000371625.8 H0Y5A1 H0Y4L4 ENST00000446677.2 ENST00000457950.5 ENST00000640716.1 A0A1W2PPU3 Q5SQ11 ENST00000444903.2 |