PSPH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0031667Biological processresponse to nutrient levels
GO_0009612Biological processresponse to mechanical stimulus
GO_0006564Biological processL-serine biosynthetic process
GO_0001701Biological processin utero embryonic development
GO_0016311Biological processdephosphorylation
GO_0006563Biological processL-serine metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0036424Molecular functionL-phosphoserine phosphatase activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene namePSPH
Protein namePhosphoserine phosphatase (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)
Phosphoserine phosphatase
Phosphoserine phosphatase (EC 3.1.3.3)
Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)
Synonyms
DescriptionFUNCTION: Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine . L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator . May also act on O-phospho-D-serine (Probable). .

AccessionsENST00000421626.5
ENST00000424596.1
ENST00000421312.5
ENST00000275605.8
ENST00000437355.6
P78330
ENST00000419984.6
ENST00000395471.7
C9JEJ7
A0A1D5RMN5
F8WD74
ENST00000427797.5
C9JBI3