PSMC3IP | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of PSMC3IP at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	220.38	2641 / 2642	100%	7.12	703 / 705
esophagus	100%	194.20	1444 / 1445	99%	4.66	182 / 183
lung	100%	188.22	578 / 578	99%	5.37	1144 / 1155
stomach	100%	170.04	359 / 359	99%	4.09	283 / 286
skin	100%	287.97	1809 / 1809	99%	7.25	467 / 472
bladder	100%	180.90	21 / 21	99%	5.68	497 / 504
uterus	100%	228.75	170 / 170	98%	10.04	451 / 459
intestine	100%	203.66	966 / 966	98%	4.25	517 / 527
breast	100%	168.90	458 / 459	98%	4.94	1097 / 1118
prostate	100%	193.61	245 / 245	97%	3.00	485 / 502
thymus	100%	171.38	653 / 653	96%	3.13	580 / 605
ovary	100%	223.48	180 / 180	95%	2.98	407 / 430
pancreas	96%	116.67	315 / 328	98%	3.08	174 / 178
kidney	99%	144.27	88 / 89	91%	3.03	824 / 901
adrenal gland	98%	95.42	253 / 258	83%	2.46	191 / 230
liver	59%	39.22	134 / 226	59%	1.72	239 / 406
adipose	100%	159.09	1204 / 1204	0%	0	0 / 0
blood vessel	100%	182.03	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	5.06	29 / 29
spleen	100%	165.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.00	45 / 45
ureter	0%	0	0 / 0	100%	2.65	1 / 1
muscle	98%	95.71	783 / 803	0%	0	0 / 0
heart	95%	89.49	818 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	2.70	75 / 80
peripheral blood	76%	168.07	706 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007131	Biological process	reciprocal meiotic recombination
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0010774	Biological process	meiotic strand invasion involved in reciprocal meiotic recombination
GO_0000709	Biological process	meiotic joint molecule formation
GO_0007129	Biological process	homologous chromosome pairing at meiosis
GO_0000794	Cellular component	condensed nuclear chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0120231	Cellular component	DNA recombinase auxiliary factor complex
GO_0003690	Molecular function	double-stranded DNA binding
GO_0120230	Molecular function	recombinase activator activity
GO_0030374	Molecular function	nuclear receptor coactivator activity
GO_0005515	Molecular function	protein binding

Gene name	PSMC3IP
Protein name	Homologous-pairing protein 2 homolog Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein) PSMC3 interacting protein
Synonyms	TBPIP hCG_16948 HOP2
Description	FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. .
Accessions	ENST00000393795.8 [Q9P2W1-1] K7EK12 K7ERB6 ENST00000253789.9 [Q9P2W1-2] K7ELD8 ENST00000586337.5 ENST00000590931.1 ENST00000588544.5 ENST00000587209.5 K7EQS1 Q9P2W1 A0A158RUX1 ENST00000590760.5 [Q9P2W1-3]

PSMC3IP report