PSMB11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PSMB11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PSMB11 at tissue level.

III. Associated gene sets

GO_0033077Biological processT cell differentiation in thymus
GO_0043374Biological processCD8-positive, alpha-beta T cell differentiation
GO_0006508Biological processproteolysis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_0005634Cellular componentnucleus
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004298Molecular functionthreonine-type endopeptidase activity

IV. Literature review

[source]
Gene namePSMB11
Protein nameProteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t)
Synonyms
DescriptionFUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). .

AccessionsA5LHX3
ENST00000408907.5