PSMA8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PSMA8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PSMA8 at tissue level.

III. Associated gene sets

GO_0010498Biological processproteasomal protein catabolic process
GO_0051321Biological processmeiotic cell cycle
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0060631Biological processregulation of meiosis I
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0019773Cellular componentproteasome core complex, alpha-subunit complex
GO_1990111Cellular componentspermatoproteasome complex
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene namePSMA8
Protein namePSMA8 protein
Proteasome 20S subunit alpha 8
Proteasome subunit alpha type
Proteasome (Prosome, macropain) subunit, alpha type, 8, isoform CRA_b (Proteasome 20S subunit alpha 8)
Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
SynonymshCG_38481
PSMA7L
DescriptionFUNCTION: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. .

AccessionsF5GY34
ENST00000343848.10 [Q8TAA3-2]
A0A087WYS6
Q8TAA3
B0YJ74
ENST00000415576.7 [Q8TAA3-5]
Q4G1B8
ENST00000308268.10 [Q8TAA3-1]
ENST00000538664.2
ENST00000612461.1