PRX report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRX at tissue level.

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0032287Biological processperipheral nervous system myelin maintenance
GO_0008366Biological processaxon ensheathment
GO_0070161Cellular componentanchoring junction
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene namePRX
Protein namePeriaxin
SynonymsKIAA1620
DescriptionFUNCTION: Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. .

AccessionsENST00000675517.1
Q9BXM0
A0A6Q8PGK2
ENST00000324001.8 [Q9BXM0-1]
ENST00000676076.1
ENST00000674773.1 [Q9BXM0-3]
ENST00000676316.1
ENST00000675300.1
ENST00000291825.11 [Q9BXM0-2]
A0A6Q8PH11
ENST00000674005.2
ENST00000675484.1
A0A6Q8PFP7
ENST00000673881.1 [Q9BXM0-3]
A0A6Q8PFM7
ENST00000676260.1
A0A6Q8PHM6
ENST00000675339.1
A0A6Q8PFW6
A0A669KBF1
A0A6Q8PGB6