PRKCG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0043278Biological processresponse to morphine
GO_0007611Biological processlearning or memory
GO_0007635Biological processchemosensory behavior
GO_0032425Biological processpositive regulation of mismatch repair
GO_1990911Biological processresponse to psychosocial stress
GO_0060291Biological processlong-term synaptic potentiation
GO_1901799Biological processnegative regulation of proteasomal protein catabolic process
GO_0042752Biological processregulation of circadian rhythm
GO_0035556Biological processintracellular signal transduction
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0048265Biological processresponse to pain
GO_0007268Biological processchemical synaptic transmission
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0050764Biological processregulation of phagocytosis
GO_0016310Biological processphosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0009636Biological processresponse to toxic substance
GO_0032095Biological processregulation of response to food
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0060384Biological processinnervation
GO_0048511Biological processrhythmic process
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0097060Cellular componentsynaptic membrane
GO_0030425Cellular componentdendrite
GO_0005911Cellular componentcell-cell junction
GO_0044305Cellular componentcalyx of Held
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0099524Cellular componentpostsynaptic cytosol
GO_0099523Cellular componentpresynaptic cytosol
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0004698Molecular functioncalcium,diacylglycerol-dependent serine/threonine kinase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCG
Protein nameProtein kinase C gamma
Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)
Protein kinase C (EC 2.7.11.13)
SynonymsPKCG
DescriptionFUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). .

AccessionsM0R0Z4
ENST00000419486.1
A0A804HHY0
ENST00000474397.5
ENST00000479081.5
P05129
A0A804HIU5
ENST00000683513.1
ENST00000263431.4 [P05129-1]
M0R0I9
H7BZ60
ENST00000682028.1