PRKAG3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRKAG3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRKAG3 at tissue level.

III. Associated gene sets

GO_0005978Biological processglycogen biosynthetic process
GO_0006096Biological processglycolytic process
GO_0031669Biological processcellular response to nutrient levels
GO_0006633Biological processfatty acid biosynthetic process
GO_0035556Biological processintracellular signal transduction
GO_0050790Biological processregulation of catalytic activity
GO_0006468Biological processprotein phosphorylation
GO_0014873Biological processresponse to muscle activity involved in regulation of muscle adaptation
GO_0005615Cellular componentextracellular space
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019887Molecular functionprotein kinase regulator activity
GO_0016208Molecular functionAMP binding
GO_0019901Molecular functionprotein kinase binding
GO_0004679Molecular functionAMP-activated protein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKAG3
Protein nameProtein kinase AMP-activated non-catalytic subunit gamma 3
Protein kinase AMP-activated non-catalytic subunit gamma 3 (cDNA FLJ60036, highly similar to 5'-AMP-activated protein kinase subunit gamma-3)
5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)
Alternative protein PRKAG3
SynonymsAMPKG3
DescriptionFUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism . In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism . It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. .

AccessionsC9JIC7
B4DUK8
Q9UGI9
ENST00000430489.1
ENST00000470307.6
ENST00000439262.7 [Q9UGI9-1]
L8EAW7
ENST00000529249.5 [Q9UGI9-1]