PRICKLE3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRICKLE3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRICKLE3 at tissue level.

III. Associated gene sets

GO_0030030Biological processcell projection organization
GO_0008150Biological processbiological_process
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene namePRICKLE3
Protein namePrickle planar cell polarity protein 3
Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6)
SynonymsLMO6
DescriptionFUNCTION: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) . .

AccessionsF5H4N2
O43900
ENST00000540849.5
H7BZP7
ENST00000376317.4
ENST00000453382.5
H0Y413
A0A0A0MRT7
ENST00000599218.6 [O43900-1]
ENST00000432913.5