PRC1 | OmnibusX

Name	Number of supported studies	Average coverage
erythrocyte	3 studies	33% ± 13%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRC1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	90%	934.15	1295 / 1445	36%	0.56	66 / 183
ovary	98%	519.58	176 / 180	16%	0.24	69 / 430
stomach	91%	540.30	328 / 359	21%	0.32	59 / 286
intestine	90%	625.39	871 / 966	19%	0.28	98 / 527
skin	100%	2760.66	1801 / 1809	1%	0.01	3 / 472
breast	100%	442.25	457 / 459	1%	0.01	6 / 1118
lung	96%	567.03	556 / 578	4%	0.05	45 / 1155
spleen	100%	672.57	240 / 241	0%	0	0 / 0
blood vessel	98%	525.65	1312 / 1335	0%	0	0 / 0
uterus	95%	367.50	162 / 170	3%	0.04	13 / 459
bladder	90%	263.76	19 / 21	7%	0.10	35 / 504
adipose	96%	440.18	1152 / 1204	0%	0	0 / 0
prostate	88%	269.69	215 / 245	0%	0	0 / 502
thymus	85%	268.77	557 / 653	0%	0	0 / 605
brain	82%	479.21	2167 / 2642	1%	0.01	4 / 705
pancreas	81%	249.71	267 / 328	1%	0.01	1 / 178
adrenal gland	78%	311.89	202 / 258	0%	0	0 / 230
heart	65%	208.45	560 / 861	0%	0	0 / 0
peripheral blood	59%	1567.93	545 / 929	0%	0	0 / 0
kidney	48%	178.24	43 / 89	0%	0.00	1 / 901
muscle	34%	78.82	277 / 803	0%	0	0 / 0
liver	15%	93.86	33 / 226	0%	0	0 / 406
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000022	Biological process	mitotic spindle elongation
GO_0051301	Biological process	cell division
GO_0051256	Biological process	mitotic spindle midzone assembly
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0032465	Biological process	regulation of cytokinesis
GO_0005876	Cellular component	spindle microtubule
GO_0030496	Cellular component	midbody
GO_0005886	Cellular component	plasma membrane
GO_0000922	Cellular component	spindle pole
GO_0005654	Cellular component	nucleoplasm
GO_1990023	Cellular component	mitotic spindle midzone
GO_0045171	Cellular component	intercellular bridge
GO_0070938	Cellular component	contractile ring
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0005694	Cellular component	chromosome
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0019901	Molecular function	protein kinase binding
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0019894	Molecular function	kinesin binding

Gene name	PRC1
Protein name	Protein regulator of cytokinesis 1
Synonyms
Description	FUNCTION: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression . .
Accessions	O43663 ENST00000361188.9 [O43663-4] ENST00000557905.5 G3V3N7 H3BSJ8 H0YNE4 ENST00000442656.6 [O43663-3] ENST00000556972.6 ENST00000560423.5 ENST00000559811.1 H0YM42 H0YLA0 ENST00000394249.8 [O43663-1] H0YL53 ENST00000555455.5 ENST00000559828.1

PRC1 report