PPP1R3B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PPP1R3B at tissue level.

III. Associated gene sets

GO_0005979Biological processregulation of glycogen biosynthetic process
GO_0005981Biological processregulation of glycogen catabolic process
GO_0005977Biological processglycogen metabolic process
GO_0000164Cellular componentprotein phosphatase type 1 complex
GO_0042587Cellular componentglycogen granule
GO_2001069Molecular functionglycogen binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding
GO_0050196Molecular function[phosphorylase] phosphatase activity

IV. Literature review

[source]
Gene namePPP1R3B
Protein nameProtein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)
SynonymsPPP1R4
DescriptionFUNCTION: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). .

AccessionsENST00000519699.1
ENST00000310455.4
ENST00000644687.1
Q86XI6
ENST00000645121.2