Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD16-positive, CD56-dim natural killer cell, human | 5 studies | 20% ± 3% | |
| epithelial cell | 5 studies | 27% ± 9% | |
| glutamatergic neuron | 4 studies | 36% ± 17% | |
| endothelial cell | 3 studies | 27% ± 8% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| GABAergic neuron | 3 studies | 36% ± 13% | |
| astrocyte | 3 studies | 23% ± 4% | |
| macrophage | 3 studies | 18% ± 0% | |
| neuron | 3 studies | 22% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 28% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3995.69 | 245 / 245 | 100% | 26.22 | 502 / 502 |
| stomach | 100% | 2742.81 | 359 / 359 | 100% | 19.54 | 286 / 286 |
| esophagus | 100% | 3286.48 | 1444 / 1445 | 100% | 21.88 | 183 / 183 |
| thymus | 100% | 6089.40 | 653 / 653 | 100% | 25.93 | 604 / 605 |
| skin | 100% | 3011.58 | 1809 / 1809 | 100% | 23.60 | 471 / 472 |
| lung | 100% | 2910.06 | 578 / 578 | 100% | 22.21 | 1151 / 1155 |
| breast | 100% | 2750.65 | 459 / 459 | 99% | 21.73 | 1112 / 1118 |
| intestine | 100% | 3200.48 | 966 / 966 | 99% | 19.63 | 523 / 527 |
| bladder | 100% | 3054.14 | 21 / 21 | 99% | 20.59 | 500 / 504 |
| kidney | 100% | 3353.78 | 89 / 89 | 99% | 18.38 | 893 / 901 |
| pancreas | 100% | 3069.66 | 328 / 328 | 99% | 18.52 | 176 / 178 |
| uterus | 100% | 3187.18 | 170 / 170 | 99% | 20.66 | 453 / 459 |
| ovary | 100% | 2456.16 | 180 / 180 | 99% | 15.35 | 424 / 430 |
| brain | 98% | 1960.75 | 2602 / 2642 | 100% | 21.06 | 705 / 705 |
| adrenal gland | 100% | 3239.12 | 258 / 258 | 97% | 13.61 | 223 / 230 |
| liver | 100% | 2084.12 | 226 / 226 | 95% | 14.00 | 384 / 406 |
| adipose | 100% | 2286.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 19.31 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 23.23 | 29 / 29 |
| spleen | 100% | 4016.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 21.29 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.58 | 1 / 1 |
| muscle | 100% | 2087.87 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2357.22 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1979.52 | 851 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 94% | 1836.23 | 872 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006457 | Biological process | protein folding |
| GO_0008380 | Biological process | RNA splicing |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0006397 | Biological process | mRNA processing |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0071013 | Cellular component | catalytic step 2 spliceosome |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0034450 | Molecular function | ubiquitin-ubiquitin ligase activity |
| GO_0016018 | Molecular function | cyclosporin A binding |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003755 | Molecular function | peptidyl-prolyl cis-trans isomerase activity |
| Gene name | PPIL2 |
| Protein name | RING-type E3 ubiquitin transferase (EC 2.3.2.27) RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2) Peptidylprolyl isomerase like 2 Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP) Peptidylprolyl isomerase (Cyclophilin)-like 2, isoform CRA_d (Peptidylprolyl isomerase like 2) |
| Synonyms | hCG_32559 |
| Description | FUNCTION: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation . May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). . |
| Accessions | ENST00000681791.1 ENST00000458567.5 A0A7P0T9A5 ENST00000406385.1 [Q13356-1] ENST00000681338.1 A0A7P0T839 A0A7P0TA15 ENST00000679692.1 ENST00000679580.1 ENST00000680109.1 ENST00000679534.1 [Q13356-1] A0A7P0TB19 A0A7P0T843 ENST00000679540.1 [Q13356-1] ENST00000681137.1 ENST00000680393.1 [Q13356-1] ENST00000681394.1 A0A7P0T8E8 Q13356 A0A7P0Z4K4 ENST00000335025.12 [Q13356-1] A0A7P0T896 F8WC56 ENST00000680061.1 [Q13356-1] A0A7P0TBL3 ENST00000680962.1 ENST00000626352.2 [Q13356-2] ENST00000417788.5 A0A7P0T8P6 ENST00000679477.1 ENST00000680860.1 C9JDF0 ENST00000679827.1 ENST00000680094.1 ENST00000680434.1 A0A7P0TAH4 ENST00000398831.8 [Q13356-1] ENST00000679795.1 [Q13356-1] ENST00000681956.1 [Q13356-1] |
