PON3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001038Biological processregulation of cellular response to drug
GO_0009636Biological processresponse to toxic substance
GO_0003096Biological processrenal sodium ion transport
GO_1901335Biological processlactone catabolic process
GO_0032929Biological processnegative regulation of superoxide anion generation
GO_0051649Biological processestablishment of localization in cell
GO_0046395Biological processcarboxylic acid catabolic process
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0004063Molecular functionaryldialkylphosphatase activity
GO_0102007Molecular functionacyl-L-homoserine-lactone lactonohydrolase activity
GO_0046872Molecular functionmetal ion binding
GO_0004064Molecular functionarylesterase activity

IV. Literature review

[source]
Gene namePON3
Protein nameSerum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)
Paraoxonase 3
Paraoxonase (EC 3.1.1.2)
Synonyms
DescriptionFUNCTION: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. .

AccessionsENST00000265627.10
F8WBV4
ENST00000451904.5
ENST00000442770.5
ENST00000427422.5
C9JZ99
F2Z2L3
Q15166
ENST00000456855.5
ENST00000418617.5
F8WD41