POLR3E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_0042797Biological processtRNA transcription by RNA polymerase III
GO_0045087Biological processinnate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex

IV. Literature review

[source]
Gene namePOLR3E
Protein nameDNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
RNA polymerase III subunit E
SynonymsKIAA1452
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway . .

AccessionsENST00000563024.5
H3BSI5
H3BSM3
ENST00000564750.5
H3BMR4
ENST00000359210.8 [Q9NVU0-2]
ENST00000299853.10 [Q9NVU0-1]
ENST00000565358.5
H3BRY1
A0A0C4DH01
ENST00000639550.2 [Q9NVU0-1]
H3BNJ0
ENST00000640588.2 [Q9NVU0-1]
Q9NVU0
ENST00000564209.5 [Q9NVU0-4]
ENST00000564883.5
ENST00000569757.1
ENST00000561494.5
H3BM46
H3BS41
ENST00000565551.5
ENST00000418581.6 [Q9NVU0-5]
ENST00000615879.4