POLR2D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0016607Cellular componentnuclear speck
GO_0005665Cellular componentRNA polymerase II, core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0031369Molecular functiontranslation initiation factor binding
GO_0005515Molecular functionprotein binding
GO_0000166Molecular functionnucleotide binding

IV. Literature review

[source]
Gene namePOLR2D
Protein nameDNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)
Uncharacterized protein POLR2D
RNA polymerase II subunit D
Synonyms
DescriptionFUNCTION: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA. .

AccessionsO15514
ENST00000409698.1
ENST00000272645.9
E9PHV4
Q53T47
E9PB93
ENST00000409955.1
Q587J0