POLG2 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	22% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLG2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	538.08	1445 / 1445	100%	8.80	183 / 183
bladder	100%	718.76	21 / 21	100%	8.94	503 / 504
uterus	100%	1007.60	170 / 170	100%	9.22	458 / 459
ovary	100%	1254.16	180 / 180	100%	8.24	429 / 430
breast	100%	753.95	459 / 459	99%	9.53	1111 / 1118
lung	100%	684.02	577 / 578	99%	9.51	1149 / 1155
intestine	100%	765.72	966 / 966	99%	7.63	522 / 527
thymus	100%	1019.37	653 / 653	99%	7.85	599 / 605
prostate	100%	829.22	245 / 245	98%	6.22	494 / 502
stomach	100%	502.65	359 / 359	98%	7.31	281 / 286
pancreas	100%	475.66	327 / 328	98%	7.72	175 / 178
brain	96%	318.42	2534 / 2642	100%	8.32	703 / 705
skin	100%	638.96	1809 / 1809	95%	8.48	448 / 472
kidney	100%	648.54	89 / 89	92%	8.31	829 / 901
liver	100%	404.79	226 / 226	91%	5.31	371 / 406
adrenal gland	100%	726.63	258 / 258	88%	3.89	202 / 230
adipose	100%	704.15	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	11.89	29 / 29
spleen	100%	1177.63	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.40	1 / 1
blood vessel	100%	539.95	1334 / 1335	0%	0	0 / 0
muscle	100%	396.51	799 / 803	0%	0	0 / 0
heart	98%	421.03	848 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	6.43	44 / 45
peripheral blood	88%	504.72	820 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	70%	3.68	56 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0071897	Biological process	DNA biosynthetic process
GO_0006264	Biological process	mitochondrial DNA replication
GO_0001701	Biological process	in utero embryonic development
GO_1900264	Biological process	positive regulation of DNA-directed DNA polymerase activity
GO_0006261	Biological process	DNA-templated DNA replication
GO_0005760	Cellular component	gamma DNA polymerase complex
GO_0005759	Cellular component	mitochondrial matrix
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0003690	Molecular function	double-stranded DNA binding
GO_0003887	Molecular function	DNA-directed DNA polymerase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0070182	Molecular function	DNA polymerase binding
GO_0030337	Molecular function	DNA polymerase processivity factor activity

Gene name	POLG2
Protein name	DNA polymerase gamma 2, accessory subunit DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) DNA polymerase subunit gamma-2, mitochondrial
Synonyms	hCG_28169 MTPOLB
Description	FUNCTION: Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. .
Accessions	E5KS15 A0A5F9ZH93 ENST00000539111.7 J3KRM2 ENST00000581355.1 ENST00000671755.1 Q9UHN1 A0A5F9ZHX9 ENST00000578997.1 ENST00000673460.1 J3QRU9

POLG2 report