POLD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006271Biological processDNA strand elongation involved in DNA replication
GO_0071897Biological processDNA biosynthetic process
GO_0006298Biological processmismatch repair
GO_0006297Biological processnucleotide-excision repair, DNA gap filling
GO_0042276Biological processerror-prone translesion synthesis
GO_1904161Biological processDNA synthesis involved in UV-damage excision repair
GO_0000731Biological processDNA synthesis involved in DNA repair
GO_0006261Biological processDNA-templated DNA replication
GO_0005654Cellular componentnucleoplasm
GO_0043625Cellular componentdelta DNA polymerase complex
GO_0016035Cellular componentzeta DNA polymerase complex
GO_0005737Cellular componentcytoplasm
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOLD3
Protein namePOLD3 protein
DNA polymerase delta subunit 3
DNA polymerase delta 3, accessory subunit
DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68)
SynonymsKIAA0039
DescriptionFUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex . As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA . Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 . Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated . Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites . Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) . Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion . Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 . .

AccessionsH0YD46
ENST00000531615.1
Q05BV7
ENST00000527458.5 [Q15054-2]
ENST00000263681.7 [Q15054-1]
Q15054
ENST00000530511.5
ENST00000532954.1
ENST00000532497.5 [Q15054-3]
Q8WUF6
E9PRK3
H0YEX7
Q569I8
E9PNC0
E9PM91
ENST00000528481.5
ENST00000524752.1