POGLUT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060537Biological processmuscle tissue development
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0010470Biological processregulation of gastrulation
GO_0048318Biological processaxial mesoderm development
GO_0018242Biological processprotein O-linked glycosylation via serine
GO_0072359Biological processcirculatory system development
GO_0007369Biological processgastrulation
GO_0006493Biological processprotein O-linked glycosylation
GO_0001756Biological processsomitogenesis
GO_0048339Biological processparaxial mesoderm development
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0012505Cellular componentendomembrane system
GO_0046527Molecular functionglucosyltransferase activity
GO_0140562Molecular functionEGF-domain serine xylosyltransferase activity
GO_0035251Molecular functionUDP-glucosyltransferase activity
GO_0035252Molecular functionUDP-xylosyltransferase activity
GO_0140561Molecular functionEGF-domain serine glucosyltransferase activity

IV. Literature review

[source]
Gene namePOGLUT1
Protein nameProtein O-glucosyltransferase 1 (cDNA FLJ53000, highly similar to CAP10-like 46 kDa protein)
Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63)
Protein O-glucosyltransferase 1
SynonymsC3orf9
MDSRP
UNQ490/PRO1006
CLP46
KTELC1
MDS010
DescriptionFUNCTION: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C . Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 . Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development . Notch glucosylation does not affect Notch ligand binding . Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). .

AccessionsB4DVA9
F8WEW4
ENST00000476573.5
ENST00000647766.1
Q8NBL1
H7C5H0
ENST00000486607.5
ENST00000497447.5
ENST00000295588.9
ENST00000460339.1
F8WDC4