PNPLA6 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	10 studies	26% ± 12%	Explore
non-classical monocyte	8 studies	26% ± 13%	Explore
alveolar macrophage	7 studies	38% ± 9%	Explore
monocyte	6 studies	25% ± 7%	Explore
classical monocyte	5 studies	25% ± 8%	Explore
endothelial cell	4 studies	19% ± 2%	Explore
conventional dendritic cell	3 studies	27% ± 5%	Explore
neuron	3 studies	20% ± 5%	Explore
myeloid cell	3 studies	20% ± 3%	Explore
epithelial cell	3 studies	19% ± 1%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	28% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4797.32	1445 / 1445	100%	29.90	183 / 183
uterus	100%	4893.52	170 / 170	100%	29.91	459 / 459
thymus	100%	5495.24	653 / 653	100%	35.93	604 / 605
ovary	100%	3878.86	180 / 180	100%	31.56	429 / 430
brain	100%	5184.56	2635 / 2642	100%	47.50	705 / 705
skin	100%	3974.81	1808 / 1809	100%	48.35	471 / 472
prostate	100%	5153.42	245 / 245	99%	24.55	499 / 502
intestine	100%	5504.69	966 / 966	99%	34.72	523 / 527
lung	100%	9573.52	578 / 578	99%	28.83	1146 / 1155
adrenal gland	100%	5498.77	258 / 258	99%	37.98	228 / 230
kidney	100%	5188.09	89 / 89	99%	28.81	893 / 901
stomach	99%	3458.62	357 / 359	100%	33.79	285 / 286
breast	100%	3832.90	459 / 459	99%	25.87	1103 / 1118
bladder	100%	5410.86	21 / 21	99%	34.96	497 / 504
liver	99%	2711.63	224 / 226	99%	20.77	403 / 406
pancreas	96%	2022.39	316 / 328	99%	32.56	177 / 178
adipose	100%	3836.35	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	40.57	80 / 80
lymph node	0%	0	0 / 0	100%	48.63	29 / 29
muscle	100%	4142.52	803 / 803	0%	0	0 / 0
spleen	100%	9534.92	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	33.94	45 / 45
ureter	0%	0	0 / 0	100%	21.06	1 / 1
blood vessel	100%	4554.55	1333 / 1335	0%	0	0 / 0
peripheral blood	100%	8155.44	926 / 929	0%	0	0 / 0
heart	98%	2769.46	842 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0046475	Biological process	glycerophospholipid catabolic process
GO_0046470	Biological process	phosphatidylcholine metabolic process
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0004622	Molecular function	lysophospholipase activity
GO_0102545	Molecular function	phosphatidyl phospholipase B activity

Gene name	PNPLA6
Protein name	Patatin like phospholipase domain containing 6 Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase) Mutant PNPLA6 protein PNPLA6 protein
Synonyms	NTE
Description	FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids . Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides . .
Accessions	A0A0B4NFS2 A0A0B4NF33 ENST00000601001.5 ENST00000600737.6 M0R2C2 ENST00000545201.6 [Q8IY17-5] M0QXH7 M0QYF5 ENST00000601668.5 Q8IY17 A0A0B4NEY1 M0QYT1 ENST00000596515.5 ENST00000414982.7 [Q8IY17-4] A0A0B4NFD1 ENST00000599947.1 M0R2H4 ENST00000593924.5 A0A384DVU0 A0A2R8Y7E1 M0QZD1 ENST00000450331.7 [Q8IY17-2] M0QZK5 ENST00000646984.1 ENST00000221249.10 [Q8IY17-2] ENST00000594551.1 ENST00000595264.5 M0R2K2 ENST00000600942.5

PNPLA6 report