PLXNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050772Biological processpositive regulation of axonogenesis
GO_0010976Biological processpositive regulation of neuron projection development
GO_2001222Biological processregulation of neuron migration
GO_0007162Biological processnegative regulation of cell adhesion
GO_0001932Biological processregulation of protein phosphorylation
GO_1904861Biological processexcitatory synapse assembly
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0043087Biological processregulation of GTPase activity
GO_0030334Biological processregulation of cell migration
GO_0001843Biological processneural tube closure
GO_0045727Biological processpositive regulation of translation
GO_0007420Biological processbrain development
GO_0008360Biological processregulation of cell shape
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0007405Biological processneuroblast proliferation
GO_0002116Cellular componentsemaphorin receptor complex
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0017154Molecular functionsemaphorin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLXNB2
Protein namePlexin-B2 (MM1)
PLXNB2 protein
Plexin B2
SynonymsKIAA0315
DescriptionFUNCTION: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton . Plays a role in axon guidance, invasive growth and cell migration . May modulate the activity of RAC1 and CDC42 (By similarity). .

AccessionsA6QRG9
A6QRH1
E2PU09
H0Y6J7
ENST00000359337.9
ENST00000432455.5
ENST00000449103.5
ENST00000425954.1
ENST00000427829.1
H0Y7X5
Q2TBE4
A0PK02
ENST00000411680.1
ENST00000434732.1
O15031