PLPP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0090279Biological processregulation of calcium ion import
GO_0001835Biological processblastocyst hatching
GO_0046839Biological processphospholipid dephosphorylation
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0000810Molecular functiondiacylglycerol diphosphate phosphatase activity
GO_0008195Molecular functionphosphatidate phosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLPP4
Protein namePhospholipid phosphatase 4 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1A)
SynonymsDPPL2
PPAPDC1
PPAPDC1A
DescriptionFUNCTION: Magnesium-independent phospholipid phosphatase with broad substrate specificity . Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate . Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol . .

AccessionsENST00000398250.6 [Q5VZY2-1]
Q5VZY2