Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| squamous epithelial cell | 3 studies | 55% ± 24% | |
| classical monocyte | 3 studies | 21% ± 3% | |
| non-classical monocyte | 3 studies | 24% ± 7% | |
| endothelial cell | 3 studies | 21% ± 4% | |
| epithelial cell | 3 studies | 34% ± 7% | |
| macrophage | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of PLEKHM1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4944.74 | 1445 / 1445 | 100% | 23.61 | 183 / 183 |
| intestine | 100% | 2391.05 | 966 / 966 | 100% | 14.62 | 527 / 527 |
| skin | 100% | 3493.15 | 1809 / 1809 | 100% | 12.31 | 472 / 472 |
| stomach | 100% | 1837.99 | 359 / 359 | 100% | 15.00 | 286 / 286 |
| uterus | 100% | 2295.66 | 170 / 170 | 100% | 11.45 | 459 / 459 |
| ovary | 100% | 2045.45 | 180 / 180 | 100% | 10.97 | 429 / 430 |
| thymus | 100% | 2990.20 | 652 / 653 | 100% | 15.46 | 604 / 605 |
| prostate | 100% | 2680.93 | 245 / 245 | 100% | 9.16 | 500 / 502 |
| lung | 100% | 3301.80 | 578 / 578 | 100% | 14.49 | 1150 / 1155 |
| bladder | 100% | 2592.14 | 21 / 21 | 99% | 12.91 | 501 / 504 |
| breast | 100% | 2725.18 | 459 / 459 | 99% | 10.54 | 1111 / 1118 |
| brain | 99% | 2181.79 | 2625 / 2642 | 100% | 14.66 | 705 / 705 |
| kidney | 100% | 1683.28 | 89 / 89 | 99% | 10.17 | 893 / 901 |
| adrenal gland | 100% | 2805.57 | 258 / 258 | 99% | 11.73 | 227 / 230 |
| pancreas | 96% | 1095.15 | 315 / 328 | 100% | 16.31 | 178 / 178 |
| liver | 96% | 1052.22 | 218 / 226 | 97% | 5.70 | 393 / 406 |
| adipose | 100% | 2809.32 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 10.74 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 11.33 | 29 / 29 |
| spleen | 100% | 3449.49 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 14.27 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.91 | 1 / 1 |
| blood vessel | 100% | 2115.19 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2260.89 | 799 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 4000.82 | 924 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 1596.81 | 848 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0015031 | Biological process | protein transport |
| GO_1900029 | Biological process | positive regulation of ruffle assembly |
| GO_0061909 | Biological process | autophagosome-lysosome fusion |
| GO_0032418 | Biological process | lysosome localization |
| GO_1902774 | Biological process | late endosome to lysosome transport |
| GO_0045780 | Biological process | positive regulation of bone resorption |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005730 | Cellular component | nucleolus |
| GO_0120281 | Cellular component | autolysosome membrane |
| GO_0005764 | Cellular component | lysosome |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0044754 | Cellular component | autolysosome |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PLEKHM1 |
| Protein name | Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162) Pleckstrin homology and RUN domain containing M1 Pleckstrin homology and RUN domain containing M1 (Pleckstrin homology domain-containing family M member 1) |
| Synonyms | KIAA0356 |
| Description | FUNCTION: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes . Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion . Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 . May have a role in sialyl-lex-mediated transduction of apoptotic signals . Involved in bone resorption (By similarity). .; FUNCTION: (Microbial infection) In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. . |
| Accessions | ENST00000632050.1 A0A8V8TPW0 ENST00000582119.6 ENST00000586562.6 ENST00000633998.1 A0A8V8TPC5 A0A8V8TQN1 ENST00000446609.7 ENST00000700132.1 K7EMP2 ENST00000617688.2 ENST00000627693.1 Q9Y4G2 ENST00000430334.8 K7EPF2 ENST00000633460.1 ENST00000584420.1 ENST00000629244.1 A0A8V8TQZ6 ENST00000630038.2 ENST00000700130.1 J3KRL8 ENST00000700129.1 A0A8V8TPC1 ENST00000700125.1 ENST00000631629.1 ENST00000629153.2 ENST00000590991.1 ENST00000700123.1 ENST00000700128.1 ENST00000586084.1 ENST00000631322.1 ENST00000700124.1 ENST00000633029.1 ENST00000589780.5 ENST00000579197.5 ENST00000446609.6 ENST00000631843.1 J3KS30 A0A8V8TQZ8 ENST00000581448.5 ENST00000700131.1 ENST00000628743.2 ENST00000613787.3 ENST00000628145.2 ENST00000633981.1 A0A8V8TPW4 ENST00000626666.1 K7EQ68 ENST00000591580.1 ENST00000633444.1 J3KRU0 K7EII8 |
