PLEKHH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030835Biological processnegative regulation of actin filament depolymerization
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePLEKHH2
Protein namePleckstrin homology, MyTH4 and FERM domain containing H2
Pleckstrin homology domain-containing family H member 2
SynonymsKIAA2028
DescriptionFUNCTION: In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.

AccessionsENST00000282406.9 [Q8IVE3-1]
ENST00000490038.1
Q8IVE3
E5RGK1
ENST00000491692.5
H0YBV1