PLD6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLD6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLD6 at tissue level.

III. Associated gene sets

GO_0034587Biological processpiRNA processing
GO_0051321Biological processmeiotic cell cycle
GO_0030719Biological processP granule organization
GO_0008053Biological processmitochondrial fusion
GO_0007286Biological processspermatid development
GO_0010636Biological processpositive regulation of mitochondrial fusion
GO_0016042Biological processlipid catabolic process
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005739Cellular componentmitochondrion
GO_0035755Molecular functioncardiolipin hydrolase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0016891Molecular functionRNA endonuclease activity, producing 5'-phosphomonoesters
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePLD6
Protein nameMitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog)
Synonyms
DescriptionFUNCTION: Presents phospholipase and nuclease activities, depending on the different physiological conditions . Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity . Plays a key role in mitochondrial fusion and fission via its phospholipase activity . In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid . Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission . Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis . Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation . Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation . The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis . Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs . Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner (By similarity). .

AccessionsENST00000321560.4
Q8N2A8