PLAAT2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLAAT2 at tissue level.

III. Associated gene sets

GO_0070292Biological processN-acylphosphatidylethanolamine metabolic process
GO_0036152Biological processphosphatidylethanolamine acyl-chain remodeling
GO_0016042Biological processlipid catabolic process
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0004623Molecular functionphospholipase A2 activity
GO_0016410Molecular functionN-acyltransferase activity
GO_0008970Molecular functionphospholipase A1 activity
GO_0016746Molecular functionacyltransferase activity
GO_0052739Molecular functionphosphatidylserine 1-acylhydrolase activity
GO_0052740Molecular function1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLAAT2
Protein namePhospholipase A and acyltransferase 2 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 2)
SynonymsHRASLS2
DescriptionFUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) . Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor . Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity . .

AccessionsENST00000255695.2
Q9NWW9