PLA2R1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	9 studies	26% ± 9%	Explore
endothelial cell	7 studies	23% ± 5%	Explore
glutamatergic neuron	5 studies	37% ± 20%	Explore
podocyte	5 studies	68% ± 32%	Explore
basal cell	5 studies	27% ± 13%	Explore
retinal ganglion cell	5 studies	38% ± 26%	Explore
endothelial cell of lymphatic vessel	4 studies	29% ± 13%	Explore
respiratory goblet cell	3 studies	24% ± 8%	Explore
GABAergic neuron	3 studies	49% ± 13%	Explore
adipocyte	3 studies	17% ± 1%	Explore
interneuron	3 studies	29% ± 17%	Explore
mucus secreting cell	3 studies	38% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	3 studies	32% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	99%	3874.98	455 / 459	97%	5.67	1085 / 1118
prostate	97%	1529.98	237 / 245	96%	3.39	480 / 502
thymus	100%	16402.40	653 / 653	89%	7.04	537 / 605
esophagus	89%	1589.35	1292 / 1445	96%	6.82	176 / 183
intestine	98%	1818.86	950 / 966	87%	3.20	456 / 527
bladder	90%	1813.43	19 / 21	90%	4.12	456 / 504
uterus	100%	5049.89	170 / 170	80%	3.36	368 / 459
kidney	99%	7174.81	88 / 89	79%	2.92	712 / 901
lung	85%	1210.07	491 / 578	88%	5.18	1016 / 1155
ovary	100%	5036.12	180 / 180	68%	1.58	294 / 430
adrenal gland	81%	1041.20	209 / 258	64%	1.79	148 / 230
skin	99%	5079.95	1796 / 1809	36%	1.20	171 / 472
stomach	39%	453.12	139 / 359	80%	3.35	228 / 286
blood vessel	100%	4634.86	1332 / 1335	0%	0	0 / 0
pancreas	2%	20.87	8 / 328	95%	5.82	169 / 178
adipose	97%	2292.68	1167 / 1204	0%	0	0 / 0
spleen	94%	1561.72	226 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	3.80	41 / 45
heart	46%	523.58	395 / 861	0%	0	0 / 0
brain	22%	608.14	579 / 2642	16%	0.52	115 / 705
eye	0%	0	0 / 0	20%	0.30	16 / 80
liver	3%	27.62	6 / 226	15%	0.37	61 / 406
lymph node	0%	0	0 / 0	17%	0.24	5 / 29
muscle	3%	29.48	27 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1900139	Biological process	negative regulation of arachidonic acid secretion
GO_0001819	Biological process	positive regulation of cytokine production
GO_0090238	Biological process	positive regulation of arachidonic acid secretion
GO_0043517	Biological process	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO_0090399	Biological process	replicative senescence
GO_0090403	Biological process	oxidative stress-induced premature senescence
GO_1904635	Biological process	positive regulation of podocyte apoptotic process
GO_1900138	Biological process	negative regulation of phospholipase A2 activity
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0009986	Cellular component	cell surface
GO_0043235	Cellular component	receptor complex
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0030246	Molecular function	carbohydrate binding
GO_0043274	Molecular function	phospholipase binding

IV. Literature review

[source]

Gene name	PLA2R1
Protein name	Alternative protein PLA2R1 Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)] Secretory phospholipase A2 receptor (180 kDa secretory phospholipase A2 receptor) (M-type receptor)
Synonyms	CLEC13C
Description	FUNCTION: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B . In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis . .
Accessions	ENST00000392771.1 [Q13018-2] L8E8E6 Q13018 ENST00000283243.13 [Q13018-1] B7ZML4

PLA2R1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review