PIWIL4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIWIL4 at tissue level.

III. Associated gene sets

GO_0034587Biological processpiRNA processing
GO_0051321Biological processmeiotic cell cycle
GO_0141005Biological processretrotransposon silencing by heterochromatin formation
GO_0007283Biological processspermatogenesis
GO_0010669Biological processepithelial structure maintenance
GO_0030154Biological processcell differentiation
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0006417Biological processregulation of translation
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0140965Biological processsecondary piRNA processing
GO_0005654Cellular componentnucleoplasm
GO_0071547Cellular componentpiP-body
GO_0043186Cellular componentP granule
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004521Molecular functionRNA endonuclease activity
GO_0034584Molecular functionpiRNA binding

IV. Literature review

[source]
Gene namePIWIL4
Protein namePiwi like RNA-mediated gene silencing 4
Piwi-like 4 (Drosophila), isoform CRA_a (Testis tissue sperm-binding protein Li 85P)
Piwi-like protein 4
SynonymshCG_1817581
HIWI2
PIWI
DescriptionFUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci . In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway . When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors . .

AccessionsF5GX26
A0A140VKG8
Q7Z3Z4
ENST00000446230.6 [Q7Z3Z4-2]
F5H116
ENST00000537419.1
ENST00000543336.5 [Q7Z3Z4-3]
ENST00000299001.11 [Q7Z3Z4-1]
ENST00000545603.1