PIWIL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PIWIL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIWIL3 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0006417Biological processregulation of translation
GO_0034587Biological processpiRNA processing
GO_0043186Cellular componentP granule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004521Molecular functionRNA endonuclease activity
GO_0034584Molecular functionpiRNA binding

IV. Literature review

[source]
Gene namePIWIL3
Protein namePiwi-like protein 3
Piwi like RNA-mediated gene silencing 3
Synonyms
DescriptionFUNCTION: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). .

AccessionsA0A8J9G8U8
ENST00000332271.9
E9PIP6
ENST00000527701.6
Q7Z3Z3
E9PJG9
ENST00000533313.6
ENST00000616349.5