PIF1 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIF1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	335.03	1442 / 1445	93%	6.50	171 / 183
bladder	100%	226.86	21 / 21	90%	6.64	453 / 504
intestine	100%	352.06	964 / 966	87%	5.59	457 / 527
uterus	86%	115.11	147 / 170	98%	10.48	450 / 459
stomach	87%	235.03	311 / 359	88%	4.90	252 / 286
lung	96%	166.01	555 / 578	72%	4.59	828 / 1155
skin	79%	345.12	1428 / 1809	80%	4.79	376 / 472
ovary	63%	64.42	113 / 180	84%	5.61	363 / 430
adrenal gland	96%	137.23	247 / 258	29%	1.32	66 / 230
brain	64%	66.25	1684 / 2642	52%	2.96	365 / 705
prostate	98%	275.89	240 / 245	9%	0.28	43 / 502
breast	64%	61.41	294 / 459	41%	2.02	463 / 1118
thymus	86%	93.65	563 / 653	14%	1.50	84 / 605
lymph node	0%	0	0 / 0	100%	17.94	29 / 29
spleen	100%	696.24	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.86	1 / 1
tonsil	0%	0	0 / 0	89%	9.02	40 / 45
kidney	72%	77.39	64 / 89	9%	0.33	78 / 901
adipose	80%	89.62	967 / 1204	0%	0	0 / 0
heart	78%	76.61	674 / 861	0%	0	0 / 0
blood vessel	76%	82.39	1010 / 1335	0%	0	0 / 0
pancreas	13%	9.59	41 / 328	61%	2.64	109 / 178
liver	37%	34.62	84 / 226	35%	1.58	141 / 406
peripheral blood	70%	773.32	649 / 929	0%	0	0 / 0
muscle	20%	13.16	158 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	11%	0.28	9 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0032508	Biological process	DNA duplex unwinding
GO_0006281	Biological process	DNA repair
GO_0051974	Biological process	negative regulation of telomerase activity
GO_0032204	Biological process	regulation of telomere maintenance
GO_0006260	Biological process	DNA replication
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0006310	Biological process	DNA recombination
GO_0000002	Biological process	mitochondrial genome maintenance
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0005739	Cellular component	mitochondrion
GO_0005657	Cellular component	replication fork
GO_0005654	Cellular component	nucleoplasm
GO_0000781	Cellular component	chromosome, telomeric region
GO_0042162	Molecular function	telomeric DNA binding
GO_0000287	Molecular function	magnesium ion binding
GO_0010521	Molecular function	telomerase inhibitor activity
GO_0033678	Molecular function	5'-3' DNA/RNA helicase activity
GO_0051880	Molecular function	G-quadruplex DNA binding
GO_0017116	Molecular function	single-stranded DNA helicase activity
GO_0043139	Molecular function	5'-3' DNA helicase activity
GO_0005524	Molecular function	ATP binding
GO_0016887	Molecular function	ATP hydrolysis activity

Gene name	PIF1
Protein name	ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein) ATP-dependent DNA helicase (EC 3.6.4.12)
Synonyms	C15orf20
Description	FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. .
Accessions	Q9Y645 ENST00000559239.2 [Q9H611-1] ENST00000268043.8 [Q9H611-1] ENST00000333425.10 [Q9H611-3] Q9H611

PIF1 report