I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 33% ± 11% | |
| endothelial cell | 3 studies | 21% ± 4% | |
| dendritic cell | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 33% ± 11% | |
| endothelial cell | 3 studies | 21% ± 4% | |
| dendritic cell | 3 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of PHF23 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2106.74 | 1445 / 1445 | 100% | 33.46 | 183 / 183 |
| ovary | 100% | 1530.01 | 180 / 180 | 100% | 49.54 | 430 / 430 |
| prostate | 100% | 2052.13 | 245 / 245 | 100% | 68.20 | 502 / 502 |
| skin | 100% | 2033.00 | 1809 / 1809 | 100% | 85.66 | 472 / 472 |
| stomach | 100% | 1363.76 | 359 / 359 | 100% | 34.86 | 286 / 286 |
| breast | 100% | 1626.55 | 459 / 459 | 100% | 55.38 | 1117 / 1118 |
| thymus | 100% | 1806.54 | 653 / 653 | 100% | 65.12 | 604 / 605 |
| intestine | 100% | 1945.26 | 966 / 966 | 100% | 39.17 | 526 / 527 |
| uterus | 100% | 1770.00 | 170 / 170 | 100% | 52.72 | 458 / 459 |
| lung | 100% | 1550.10 | 577 / 578 | 100% | 43.79 | 1154 / 1155 |
| brain | 100% | 1410.71 | 2632 / 2642 | 100% | 59.59 | 705 / 705 |
| bladder | 100% | 1782.33 | 21 / 21 | 100% | 46.89 | 502 / 504 |
| kidney | 100% | 1696.91 | 89 / 89 | 100% | 41.43 | 897 / 901 |
| adrenal gland | 100% | 3254.62 | 258 / 258 | 99% | 42.25 | 228 / 230 |
| liver | 100% | 1155.64 | 226 / 226 | 99% | 29.54 | 401 / 406 |
| pancreas | 97% | 703.79 | 317 / 328 | 100% | 44.54 | 178 / 178 |
| adipose | 100% | 1581.17 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 85.78 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 73.47 | 29 / 29 |
| spleen | 100% | 2294.22 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 49.37 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.88 | 1 / 1 |
| blood vessel | 100% | 1434.88 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 2606.80 | 926 / 929 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1105.45 | 793 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 923.83 | 832 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031398 | Biological process | positive regulation of protein ubiquitination |
| GO_0006914 | Biological process | autophagy |
| GO_1901097 | Biological process | negative regulation of autophagosome maturation |
| GO_1902902 | Biological process | negative regulation of autophagosome assembly |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PHF23 |
| Protein name | PHD finger protein 23 PHD finger protein 23 (PDH-containing protein JUNE-1) |
| Synonyms | hCG_42023 |
| Description | FUNCTION: Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. . |
| Accessions | I3L410 ENST00000572789.5 I3L2W6 I3L1N0 ENST00000574236.5 ENST00000573826.5 ENST00000613632.4 A0A087WVQ2 I3L0X3 I3L4Q4 ENST00000574323.5 ENST00000320316.8 [Q9BUL5-1] ENST00000571362.5 [Q9BUL5-3] Q9BUL5 ENST00000576955.5 I3L0Y2 ENST00000570899.1 ENST00000454255.6 [Q9BUL5-4] |
