PHF13 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PHF13 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PHF13 at tissue level.

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0007076Biological processmitotic chromosome condensation
GO_0006282Biological processregulation of DNA repair
GO_0051301Biological processcell division
GO_0000278Biological processmitotic cell cycle
GO_0007059Biological processchromosome segregation
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0140463Molecular functionchromatin-protein adaptor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePHF13
Protein namePHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)
Synonyms
DescriptionFUNCTION: Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response . Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 . Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis . Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation . Essential for testicular stem-cell differentiation and sustained spermatogenesis (By similarity). .

AccessionsQ86YI8
ENST00000377648.5