PGLYRP4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PGLYRP4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PGLYRP4 at tissue level.

III. Associated gene sets

GO_0009253Biological processpeptidoglycan catabolic process
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0031640Biological processkilling of cells of another organism
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0016045Biological processdetection of bacterium
GO_0045087Biological processinnate immune response
GO_0032991Cellular componentprotein-containing complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0046982Molecular functionprotein heterodimerization activity
GO_0008745Molecular functionN-acetylmuramoyl-L-alanine amidase activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0008270Molecular functionzinc ion binding
GO_0016019Molecular functionpeptidoglycan immune receptor activity

IV. Literature review

[source]
Gene namePGLYRP4
Protein namePeptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta)
SynonymsSBBI67
PGRPIB
DescriptionFUNCTION: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. .

AccessionsQ96LB8
ENST00000359650.10 [Q96LB8-1]
ENST00000368739.3 [Q96LB8-2]