PGAP6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PGAP6 at tissue level.

III. Associated gene sets

GO_0006629Biological processlipid metabolic process
GO_0008150Biological processbiological_process
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0004623Molecular functionphospholipase A2 activity
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene namePGAP6
Protein namePost-GPI attachment to proteins 6 (Transmembrane protein 8 (Five membrane-spanning domains), isoform CRA_a)
Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A)
Post-GPI attachment to proteins 6
SynonymsTMEM6
TMEM8
TMEM8A
hCG_1984172
DescriptionFUNCTION: Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells . Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane . In contrast to myomaker (TMEM8C), has no fusogenic activity . .

AccessionsENST00000250930.7
H0Y5B2
H7C1S0
ENST00000427313.5
ENST00000424078.5
ENST00000448854.1
C9J8D7
K4DI83
Q9HCN3
ENST00000431232.7