PFKFB1 | OmnibusX

Name	Number of supported studies	Average coverage
adipocyte	9 studies	35% ± 14%	Explore
hepatocyte	3 studies	61% ± 16%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PFKFB1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	2170.92	226 / 226	85%	19.35	346 / 406
breast	81%	807.37	373 / 459	64%	2.29	714 / 1118
muscle	100%	2040.75	803 / 803	0%	0	0 / 0
adipose	97%	1096.00	1173 / 1204	0%	0	0 / 0
thymus	60%	85.76	394 / 653	13%	0.24	77 / 605
pancreas	37%	45.10	121 / 328	21%	0.36	38 / 178
lymph node	0%	0	0 / 0	45%	0.62	13 / 29
kidney	36%	56.45	32 / 89	7%	0.13	62 / 901
prostate	2%	2.54	4 / 245	23%	0.34	116 / 502
tonsil	0%	0	0 / 0	22%	0.32	10 / 45
uterus	0%	0	0 / 170	21%	0.34	98 / 459
brain	0%	0.28	7 / 2642	20%	0.28	142 / 705
esophagus	2%	3.55	25 / 1445	19%	0.27	34 / 183
bladder	0%	0	0 / 21	18%	0.25	93 / 504
skin	8%	11.56	136 / 1809	5%	0.07	23 / 472
adrenal gland	8%	11.29	20 / 258	4%	0.08	9 / 230
lung	0%	0	0 / 578	9%	0.13	100 / 1155
blood vessel	9%	30.35	115 / 1335	0%	0	0 / 0
stomach	1%	5.61	2 / 359	8%	0.19	22 / 286
intestine	3%	8.95	26 / 966	5%	0.09	24 / 527
peripheral blood	7%	6.81	61 / 929	0%	0	0 / 0
ovary	0%	0	0 / 180	5%	0.07	21 / 430
heart	3%	5.05	29 / 861	0%	0	0 / 0
spleen	2%	2.73	4 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0046835	Biological process	carbohydrate phosphorylation
GO_1904539	Biological process	negative regulation of glycolytic process through fructose-6-phosphate
GO_0006096	Biological process	glycolytic process
GO_0006003	Biological process	fructose 2,6-bisphosphate metabolic process
GO_0006000	Biological process	fructose metabolic process
GO_0032868	Biological process	response to insulin
GO_0033762	Biological process	response to glucagon
GO_0031100	Biological process	animal organ regeneration
GO_0042594	Biological process	response to starvation
GO_0051591	Biological process	response to cAMP
GO_0051384	Biological process	response to glucocorticoid
GO_0006094	Biological process	gluconeogenesis
GO_0043540	Cellular component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
GO_0005829	Cellular component	cytosol
GO_0003873	Molecular function	6-phosphofructo-2-kinase activity
GO_0019900	Molecular function	kinase binding
GO_0004331	Molecular function	fructose-2,6-bisphosphate 2-phosphatase activity
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0070095	Molecular function	fructose-6-phosphate binding
GO_0005515	Molecular function	protein binding

Gene name	PFKFB1
Protein name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1 protein) 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 splice variant 2 (EC 3.1.3.46) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1 splice variant 3 (EC 3.1.3.46) (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1)
Synonyms	PFRX F6PK
Description	FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. . FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. . FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. . FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. .
Accessions	P16118 ENST00000545676.5 [P16118-2] I1Z9G4 Q4VBA9 ENST00000374992.6 I1Z9G3 Q4VBA8 ENST00000614686.1 ENST00000375006.8 [P16118-1]

PFKFB1 report